Desonide cream 0.05% 10g is a non-halogenated corticosteroid with anti-inflammatory, anti-allergic and antipruritic activity. There are no halogens in the desonide molecule, so its antiproliferative effect on keratinocytes and fibroblasts is insignificant, which reduces the likelihood of thinning and atrophy of tissues at the site of application. It also induces the formation of lipocortins that inhibit the activity of phospholipase A2 and inhibits the synthesis of prostaglandins and leukotrienes. Generic Desonate reduces vascular permeability, chemotaxis, contributes to the stabilization of lysosomes, has a vasoconstrictor effect with the inflammation.
Applied externally for allergic dermatitis, seborrhea, various forms of eczema, neurodermatitis, psoriasis, pruritus, red flat warty lichen. Applied topically for inflammatory diseases of the anterior segment of the eye and its appendages, allergic conjunctivitis, scaly blepharitis, episcleritis, recurrent iritis, iridocyclitis of the posterior segment of the eye, thermal and chemical corneal lesions.
For local application:
- inflammation of the anterior segment of the eye (blepharitis, conjunctivitis, scleritis, deep keratitis without epithelial damage, iritis, iridocyclitis);
- inflammation of the posterior segment of the eye (choroiditis, chorioretinitis, optic neuritis);
- prevention and treatment of inflammatory phenomena in the postoperative and post-traumatic period.
For external use:
- allergic dermatitis;
- various forms of eczema;
- red flat warty lichen.
- Hypersensitivity to desonide cream 0.05% 10g.
For local application:
- increased intraocular pressure;
- acute corneal viral diseases (including those caused by Herpes simplex) in the ulceration stage;
- conjunctivitis with ulcerative keratitis;
- tuberculosis of the eyes;
- mycosis of the eye;
- purulent ophthalmia;
- purulent conjunctivitis;
- purulent blepharitis;
For external use
- viral, fungal skin diseases;
- syphilitic skin manifestations;
- tumors of the skin.
Application with special care during
- childhood period.
Use during pregnancy
Category of action on the fetus according to the FDA-C.
Adequate and strictly controlled studies on the safety of desonide cream 0.05% 10g during pregnancy have not been conducted. It is not known whether the drug has an immediate or delayed adverse effect on the fetus.
Animal studies have shown that stronger corticosteroids are teratogenic. The use of Generic Desonate 0.05% 10g during pregnancy is possible only if there are indications, as prescribed by a doctor, if the potential benefit to the mother exceeds the possible risk to the fetus.
Use during breastfeeding
- No specific safety studies have been conducted on the use of Generic Desonate 0.05% 10g during breastfeeding.
- It is not known whether Desonide 0.05% 10g is excreted in human breast milk.
- It is recommended to stop breast-feeding if desonide cream 0.05% 10g is applied.
Dosage and administration
The dosage regimen is individual, depending on the indications, clinical situation, treatment regimen and dosage form.
Possible effects on the visual organ
With prolonged use in ophthalmological practice, it is possible to increase intraocular pressure, reduce the angle of vision, reduce visual acuity, develop cataracts and damage to the optic nerve, and perforation of the eyeball. Tingling and burning sensation at the site of application are also possible. There is little information on pharmacological interaction with other drugs.
Hypersensitivity to desonide cream 0.05% 10g.
For topical use, increased intraocular pressure, acute corneal viral diseases (including those caused by Herpes simplex) at the stage of ulceration, conjunctivitis with ulcerative keratitis, eye tuberculosis, eye mycosis, purulent ophthalmia, purulent conjunctivitis, purulent blepharitis, barley are all possible.
For external use, bacterial, viral, fungal skin diseases, skin tuberculosis, syphilitic skin manifestations, skin tumors may be present.
The drug is not recommended for use in patients with corneal injuries and abrasions. When used on large skin surfaces or when the skin is damaged, as well as when applying occlusive dressings, it is possible to increase absorption and display a resorptive effect. In diseases causing thinning of the cornea, the application of Generic Desonate may cause perforation of the cornea.
With prolonged use, it is possible to increase intraocular pressure with the development of a glaucoma symptom complex with atrophy of the optic nerve and narrowing of the visual fields (therefore, when using drugs containing glucocorticosteroids, intraocular pressure should be regularly measured for more than 10 days), corneal perforation, and fungal infection.
With constant use for more than three months, cataracts may develop.
The drug is not recommended for use when wearing contact lenses. Before using the drug, remove contact lenses and put them back on no earlier than 20-30 minutes.
When used on large skin surfaces or when the skin is damaged, as well as when using occlusive dressings, it is possible to increase absorption and display a resorptive effect.
Corticosteroid therapy can hide the current bacterial or fungal infection.
Influenced ability to drive vehicles and manage mechanisms may be one of the effects of the drug.
Due to possible lacrimation after instillation of Desonide 0.05% 10g, it is not recommended to use it immediately before driving vehicles or servicing mechanical equipment.